Avenue Biosciences - Protein engineering powered by machine learning

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SECRETORY PATHWAY OPTIMIZATION

ENGINEERING SECRETION FOR BETTER OUTCOMES IN BIOLOGICS
DEVELOPMENT

High throughput protein engineering technology for enhancing production yield and quality of your end product.

News

PRESS RELEASE

Stay informed: Announcements, key milestones, and what we are working on next.

July 16, 2026

Circio and Avenue Biosciences jointly announce research collaboration to enhance protein secretion for gene therapy

July 2, 2026

Avenue Biosciences Expands Board of Directors with Appointment of Dr. Jens Vogel

January 12, 2026

Avenue Biosciences raises $5.7M to scale the first platform modulating the secretory pathway for enhanced therapeutic protein manufacturing

Technology

ENGINEERING THE SECRETORY PATHWAY TO MAXIMIZE YIELD AND QUALITY

Signal peptide optimization significantly impacts protein biogenesis.

Each protein has specific signal peptide requirements for maximized performance.

Maintain high quality and biosimilarity for your target.

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Platform

A powerful combination of machine learning and wet lab chemistry

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Library

Large SP libraries tailored specifically for your target of interest.

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Display

Our technology measures protein secretion efficiency at individual cell level.

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DNA Analysis

Identifying SP-protein combinations that drive the highest secretory output.

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Validation

Top candidates characterized for enhanced expression and quality.

Machine learning transforming biosciences

The Technology

A BLEND OF SYNTHETIC AND ORGANIC BIOLOGY

Our platform is a unique combination of high-throughput chemistry and synthetic biology, powered by machine learning and AI algorithms.

It is the most powerful solution to engineering N-terminal signal peptides: An element significantly underutilized in protein biologics.

Enhance any protein production system: From protein biologics and biosimilars to any mammalian protein-based biotechnology tools.

APPLICATION POSSIBILITIES

ENABLE PRODUCTION OF DIFFICULT-TO-EXPRESS PROTEINS

ENHANCE PROTEIN, mRNA & VIRAL THERAPIES

SINGLE CHAIN PROTEIN EXPRESSION OPTIMIZATION

MULTI-CHAIN PROTEIN EXPRESSION OPTIMIZATION (mABS, ANTIBODIES)

BOOSTING VACCINE & DRUG DISCOVERY

MAMMALIAN CELL LINE DEVELOPMENT

THERE IS A GROWING DEMAND FOR PROTEIN-BASED BIOLOGICS AND USE OF PROTEINS AS TOOLS FOR DIAGNOSTICS.

Benefits

FEWER BOTTLENECKS, MORE BREAKTHROUGHS

Increase the success of therapeutic and biotechnology development with precise, scalable protein engineering

laboratory professional with microscope cell culture

CHALLENGES INTO VICTORIES

Reduce time-to-market and production costs in pre-clinical therapeutic development

Preclinical development process using latest technology

UNLOCK BREAKTHROUGHS FASTER

Gain a critical advantage and unique IP with novel molecular components

Unique naturally occurring and synthetic elements

OUTPACE THE COMPETITION

Laboratory professional working with precision and experience.

About

WHO WE ARE

Avenue Biosciences is a team of life science and technology visionaries. We resolve fundamental challenges in therapeutic development through powerful protein engineering that combines organic biology and machine learning. Our proprietary method is based on years of scientific research from the University of Helsinki, Finland.

This novel method has the capacity for analyzing thousands of protein expression elements at once to find a handful of promising candidates. The resulting unique molecular combinations can provide substantial value that is worth millions to therapeutic developers tapping into countless opportunities in protein biologics drug discovery.

Ville Paavilainen

Research Director, University of Helsinki