Discover our science

PROTEIN BIOGENESIS ENGINEERING FOR VARIOUS BIOTECHNOLOGY AREAS

Almost all therapeutic proteins and mRNA therapies contain a protein expression element that can be engineered for boosted production and functionality.

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Our engineered signal peptide-protein combinations outperform existing strategies and offer significant yield improvements without compromising quality.

APPLICATION POSSIBILITIES

ENABLE PRODUCTION OF DIFFICULT-TO-EXPRESS PROTEINS

ENHANCE PROTEIN, mRNA & VIRAL THERAPIES

SINGLE CHAIN PROTEIN EXPRESSION OPTIMIZATION

MULTI-CHAIN PROTEIN EXPRESSION OPTIMIZATION (mABS, ANTIBODIES)

BOOSTING VACCINE & DRUG DISCOVERY

MAMMALIAN CELL LINE DEVELOPMENT

Technology

AN UNPARALLELED COMBINATION OF YIELD AND QUALITY

N-terminal signal peptide engineering is an essential part of our protein engineering platform. We offer a robust, high throughput strategy to tailor the most optimal molecular sequence to drive significant increase in protein production efficacy without compromising the quality of the product.

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This technology enables our customers, for the first time, to maximize the value of protein biogenesis on endoplasmic reticulum level, leading to enhancements on protein folding, post-translational modifications and significantly enhanced expression.

ENGINEERING A UNIQUE ELEMENT

AMONG THOUSANDS

Our multi-thousand signal peptide (SP) libraries are a product of modern bioinformatics, years of research on protein expression, genetic engineering, and machine learning. These libraries are used to engineer the most efficient protein-coding sequence for driving optimal results in biotechnology and biopharmaceutical development.

External validation

BACKED UP BY RIGOROUS VALIDATION

Our platform has undergone rigorous external validation with numerous commercially valuable proteins. In all tested cases, the result has been significant boosting of expression yield when comparing to previously used strategies. Our results have also been independently validated in external biotechnology laboratories. The yield improvement has been replicated in stable and transient cell cultures, in different cell culture volumes, in different cell strains and by different laboratories – from milliliter to liter volume in standard industrial setting.

FROM ROADBLOCKS TO BREAKTHROUGHS

Problem

Protein expression is still a major bottleneck in the biotechnology industry. Despite all the advancements, for most proteins, production optimizations remain a long and expensive process especially in difficult-to express (DTE) proteins.

Solution

Our platform offers a unique solution to harness the full power of endoplasmic reticulum level regulation of protein biogenesis. We tailor unique molecular sequences that drive improved outcomes in protein production, from DTEs to any protein production optimization.

Machine learning and faster discovery in biotechnology.

REVOLUTIONIZING HEALTHCARE THROUGH INNOVATIVE SOLUTIONS

Discover our cutting-edge technology and services that drive advancements in biopharma.